Once I started doing it during the lockdown, one of the things I know is the runs that I do, the last hill is fucking brutal and I always finish on this last hill. And then they get in there and then I look over at them fifteen minutes in the fucking day and I'm like, yeah, it, it told you it's it's not what you think it is because you're doing like yoga even uncoupled from the heat like the hot part. You know, it's actually I was talking about my glucose monitor, my continuous glucose monitor. Well I think we covered a lot today. What if what if, you know, some some common cold coronavirus has gone around and that, you know, those antibodies that they've made to neutralize that coronavirus beta coronavirus are somehow helping with the sars-cov-2 like. The economy, again, like now, maybe like everyone could wear a mask if they're going to be inside around a bunch of people other better than keeping the economy better than keeping the economy close. But so you go and you do these different they have all these different types and I don't remember. It was like I could just I'm like, yeah, it's like having someone that snores is like, you can't sleep. First of all, there's a machine called reverse hyper. So there's a few viruses that this happens with. Vitamin D deficiency is what makes it worse. Living in scotland I could have told you that no sunshine makes you miserable, 6 hours of overcast "daylight" in the winter is pretty brutal. And like like he had been reading some studies to confirm that. She goes into the guest room to sleep, like after they go to bed because she can't sleep like it's really bad. I do, but I try not to. He's like, fuck yeah. Right. And there's been these studies where people are like untrodden intranasal, like they'll give them various titers of influenza virus and they the point of the studies to figure out what viral dose and they have like some measurement, like in in tissue culture or whatever, and they like to to make people have symptoms. #1474 - Dr. Rhonda Patrick The Joe Rogan Experience 125 Clips. And the sham control was like a green light like. And when he was talking about after the fact, what Michael was talking about was how that is proven to be correct in New York and that some monstrous number, like 80 percent of the people put on ventilators wound up dying, not just New York. So it's doing its job, but you sometimes make antibodies that are non neutralizing or don't do as good of a job. That's got to be so bad for you. And people were getting sick. No, no. And but, you know, there certain times of the year, depending on where you live and a more northern latitude where that UVB isn't even hitting the atmosphere. Now it's like, you know, did you realize how much work being a mom was for you? So it's thought, oh, well, the same we're seeing the same, you know, pattern where people with Type O are protected from sars-cov-2 possibly. COVID-19 Q&A #1 with Rhonda Patrick, Ph.D. More evidence having poor vitamin D status before infection increases COVID-19 severity and death risk. We're often asked, what is one? And so he had to go to the hospital. Yeah. Yeah. And then, so then the next day I would like look forward to doing it to see if I could do it easier again. And I say, crazy asshole. She didn't figure this out. I mean, I'm wearing it because I'm sort of trying to understand how different foods have different lifestyle changes, like how long you've been wearing it. It's an annual day dedicated to Trager that encourages our nation to grill and celebrate all things Trager and the Trager day sale is May 15th through 17th. So the point is that I think that I know people don't want to wear masks. But there is some actual legitimate research elderberry like has been shown in randomised controlled trials to like effect know the immune system and lower cold duration and stuff like that, you know. It's important, like it's important for normal immune cells, normal immune function. You'll peak at around five hours after. Well, no, I think what's actually the sauna is actually just it's improving your immune system. The cold shower, sorry, the cold shower. The one that I'm getting, it's like it's found it like Whole Foods and sprouts and it's don't have the same amount of active culture though. Saying that I want people to think I'm saying it's a treatment, I just want to it's a hypothesis that needs to be tested. So, I mean, there's and it's funny that because it's kind of connected to this antibody dependent enhancement, there's there's been quite a few different like forms like mutations that have been identified. Providing anti-inflammatory effects That's amazing, as is the pregnancy, and he's like, no, he's like we get women coming in here after, it's like worse. You know, it's something because if you if you look at the graph, it's kind of a trans intravenous vitamin C transient. June 21st 2020 In the Indonesia was a really interesting study where, like, they measured vitamin D and this was measured in the patients. So yeah. Vitamin C How other health factors, you know, and but there was a big study just released not long ago from from like the National Office of Statistics in Britain or something like that. Yes, they're getting way more sick right now because they're I mean, that could be one reason right there. I was like, I'm killing you bitches and killing all you dirty viruses. So he tracked proteins also do have antiviral activity against at least influenza A.. Legal zoom is not a law firm, so you won't have to worry about expensive billable hours adding up. So then I went they were all jumping in the lake after and I'm like, I'm going to just sit on this patio. What works. So. I did a sleep study once because of sleep apnea. There is also existing knowledge suggesting vitamin D may have a critical role in the regulation of the immune system which might include viral infection immune responses. I'm sure they can get a lot of I mean, I'm sure there's someone listening to this right now. Well, this is the very reason why people in places like Scotland and England have such pale skin. Like what are the causes? It's been like compared like twenty five minutes in the sauna. And I'm like for a little bit it's going to be nighttime soon. Distilled, aged and bottled by Buffalo Trace Distillery 90 Proof. I mean, there's a lot of different repurposing drugs that are being investigated, you know, and I think over the next couple of months and then Regeneron is already, you know, doing one of these monoclonal antibodies. It is. You're not going to leave. A two and a ten degrees. 2015 I stop, I cut that out like I finished my postdoc so I published a couple of studies. But I got addicted to it. It's like a market difference. And so like, Jesus, I have to go to bed immediately after he stops. So why do you take five. As an expert in vitamin D, Rhonda Partick has revealed her most current research regarding the effect of vitamin D including: The aging process But then when they went down to from ten to the seven, let's say they went down to ten to the five only like 10 percent. These fucking politicians now in the place where you guys have to understand these people. We were in a big I don't know what it was called, but I didn't sleep the whole night and it was awful. You'll find it. It's like like it's like my my teeth get dirtier. So my tongue slides. Pretty sure your title is a little bit on the spectrum. Just constant wear for years then. And if you need to speak to an attorney there, independent attorney network is there to guide and advise you. Adding supplements to a healthy diet will most likely not hurt anyone. She's like, fuck off staying awake. And then there's asymptomatic. So, you know, making this general statement that, oh, vitamin C supplementation doesn't do anything is not it's accurate in some respects. The FoundMyFitness Q&A happens monthly for premium members. So you keep looking down. Dude, this is really bad. Shame on me. So that I intravenous vitamin C, I think it had to be 12 and it should be twelve shots give you an awesome little boost. Right. You know, there there are some claims out there that are sort of being backed up by very poorly done studies. But there's been studies that have shown that you can I mean, people that have taken, you know, ten thousand I use a day for for multiple years, haven't had any hypoglycemia or had, you know, problems, but too much vitamin D can be toxic. That's that's intense. So people thought they were getting a treatment. And so, you know, like another really interesting kind of thing is like, you know, there's so the sars-cov-2 virus is part of a family of of coronaviruses called the beta coronaviruses. I mean, like because there's a lot of people that are deficient in vitamin D and it's a steroid hormone. We are like it's already we're already finding repurposed therapeutics, the monoclonal antibodies, people working on that. Yeah. Why can't I take my card. But it's not something that I'm certain that people need to do on a daily basis. Yeah. You should judge, but I have a hard time. I I'm a fan of Kombucha. Well, I mean, depending I you know, I really think that I think things will start we'll start to get better. How much vitamin D does Dr. Rhonda Patrick recommend? Podcast Notes is a Signal From the Noise LLC Production, All Right Reserved, Berkshire Hathaway Annual Shareholders Meeting, Christopher Lockhead's Follow Your Different, Everyday Espionage Podcast with Andrew Bustamante, Feel Better, Live More With Dr. Rangan Chatterjee, Moonshots and Mindsets with Peter Diamandis, Network State Podcast with Balaji Srinivasan, Spearhead with Naval Ravikant and Babak Nivi, The Unraveling Podcast with Jocko Willink and Darryl Cooper, This Week in Startups with Jason Calacanis, Where It Happens with Sahil Bloom and Greg Isenberg, Sauna: if you have access use the sauna regularly to improve cardiovascular health and immune functions take a hot bath if you dont have access, Theres a big difference between oral vitamin C and Intravenous vitamin C, You can take vitamin C orally but will need a big dose and it still wont have the same effect; IV once per week if you can, Sleep plays a crucial role in immunity, homeostasis, and regulation of body functions, People are actively working on monoclonal antibodies, Improved therapeutic treatments coming, including more repurposing of drugs that will make things less scary, As you get older your immune system declines, There are lifestyle components of immune system you can be proactive about: exercise, sleep, supplements, nutrition, gut-microbiome health, Besides age, the major regulator of immune function seems to be previous virus exposure, not genetics, At any given point you have antibodies against 10 different viruses but youre not always getting sick, 50-80% of US population has had CMV and most people dont ever know they have had it and show no symptoms, CMV impacts immune function differently depending on when you get it, When youre young, it enhances immune response but for older people its deleterious, Interesting tie-in to COVID-19 because we know older people are more prone to severity, Its likely that theres some cross-immunity happening since SARS-COV-2 viruses is part of beta coronaviruses along with SARS-CoV-1 and MRSA, 15-30% of common colds come from coronaviruses so theres a good hypothesis that potentially one or two of common cold virus antibodies could interact with SARS-CoV-2 and neutralize it, Antibody binds to virus and instead of neutralizing it, changes the configuration so the virus can get into the cell better, This activates the immune system and causes pathology, This results in a higher viral load without antibodies to neutralize, Weve seen it happen with coronaviruses, including SARS-CoV-1 and MRSA, The spike region is where antibodies bind and is also the region the virus uses to get into the cell, Currently seeing two major strain mutations in the spike regions one mutation more prominent in Asia, one mutation more predominant in Europe and North America, Brings to light an interesting genetic link to mutations, Theres a theory that the mutation is causing peoples immune system to become more active and lead to severe COVID-19, Monoclonal antibodies: identify specific antibody that binds to spike protein and manufacture them, Problem is this will offer short lived protection since you are not making your own antibodies as you would with a vaccine, Continuous exploration into repurposing drugs and combination drug treatments, Anecdotally, the majority of people on ventilators die partly because ventilators cause more damage to the lungs and can induce more damage, But its hard to say which came first did the ventilator do the damage or was the damage so severe that the patient needed a ventilator, People with Type O blood seem to be less susceptible to contracting COVID-19, People with Type O blood create Type A antibodies which bind to spike region and neutralize antibody so it cant enter the cell, We saw this in SARS-CoV-1 so maybe same for SARS-CoV-2, Another (unproven) theory: Type O blood people have lower levels of blood factor involved in clotting, Hearing more stories that some prisoners are trying to contract SARS-CoV-2 to get out of jail by spitting in a cup and passing to others, First off, its important to distinguish between asymptomatic and pre-symptomatic, Some people do not have symptoms at the time of testing but develop symptoms later so are actually pre-symptomatic, Its possible that viruses have already gone around that environment so antibodies from those viruses are helping in immunity from SARS-CoV-2, Rhonda was also searching to literature to see whether inmates are vaccinated prior to entering but couldnt find that information, Poor sleep has a huge impact on glucose and spikes and also plays a role in maintaining optimal immune functions, Rhonda takes melatonin to help her sleep, 10 mg/day, Regulating circadian rhythm is crucial for sleep, Rhonda makes sure to have bright light exposure in the morning (e.g., opening curtains, walking outside), and changes the lighting in the house in the evening to red lights, 70% of US population has insufficient Vitamin D levels; 28% are deficient, Body can generate naturally when exposed to sun daily, Obese people in US are also more likely to be vitamin D deficient, Genetic polymorphisms: people that have variations in genes that cause them to have less vitamin D, These people are more likely to die from respiratory infection, African Americans in the US are 28x more deficient in vitamin D than Caucasians, A recent study that looked at COVID-19 patients observed an inverse relationship between vitamin D levels and COVID-19 symptoms: the lower the vitamin D levels, the higher the severity of COVID-19, In Indonesia almost all patients that died from COVID-19 were vitamin D deficient, Melanin blocks ability to produce Vitamin D, In the US and Europe, African Americans and black people are more likely to die from COVID-19, Even when adjusting for SES and lifestyle factors, this was still true so something else must be happening, Tolerable upper intake is 4000 IUs per day but its best to get vitamin D blood test to measure levels, There are clinical studies exploring the role of vitamin D but not many in the US, Rhonda wants to see nurses and first responders take vitamin D to see the role in prevention but those studies are not being done, Joe uses the sauna 7 days/week, 180-degrees for 25 min, Rhonda uses the sauna 5 days/week, 180-degrees for 25 min, Heart rate variability improves, blood pressure goes down, cardiovascular health improves, all-cause mortality decreases, Sauna use also improves immune system and makes you more resilient against infection, Brain-derived neurotropic factors (BDNF) increases with exercise and heat stress (sauna), The positive benefits of physical activity on the cardiovascular system were enhanced when sauna was added, Sauna use increases heat shock proteins which prevent muscle atrophy, neurodegenerative genes, and have anti-depressant effects, People who sat in 160-degree sauna for 30 minutes had a 60% increase in heat shock protein compared to baseline, Large Harvard study being done to assess whether hot yoga increases heat shock protein, Heat shock protein have antiviral activity against influenza A, Regular sauna is heating ambient air which in turn raises core body temperature, Infrared saunas are directly heating body without heating the ambient air for example, in a heating tent or blanket, We know more about the effects of dry sauna, For people who dont have access to sauna, a hot bath is a good modality for heat shock protein, Studies being done to assess whether sauna can have anti-depressant effect on depressed patients, Saunas could also provide an avenue for giving sedentary and disabled people the benefits of physical activity without exercising, Ice baths and cold showers can be comparable to cryotherapy but you have to stay in the cold water longer, Cold shock protein hasnt really been measured in humans, instead whats measured is norepinephrine which has been shown to increase, Cold shock protein and hot shock protein have been shown to improve mood as well, The pharmacokinetics of vitamin C are very different in oral vs IV consumption, Oral vitamin C is good for immune function, etc. and she has reactive airways. And so he's a very smart guy and he knows so much about physical fitness and weight training. You can pick up Dr. Rhonda Patricks Vitamin D3 supplement on Amazon. It is taking five. Yeah. You know, basically it's made in the skin. Of course, he's like in the middle of the sleep and it happens earlier in my sleep cycle. So that was the Philippines. There we go. So she right now, her name is Doctor. Right. It's so there's so many variables in terms of like how people how people are affected by it and what goes wrong, because there are so many variables. Right. Have you ever done the cold shower after your sauna? Like, it sucks like that. So I have like all the apps and stuff and most of the time like and I turn my my my iPhone screen is like down and they have the black background and all that. Like I'm the kind of person where, like, I like to make people happy. He's given us gave us this new platform too. Yeah. And I you know, look, I'm going to be 42 next month, so like fifty two. I think it has huge potential. I like the ginger lemon a lot and I like this one. The results showed the safety of vitamin D supplementation in addition to the protections provided for acute respiratory tract infections. Yeah. Yeah. So so then I found out I was pregnant and so I was like, OK, well, I can't go back to the dentist. So as opposed to having a severe form, it's just like you're less likely to contract it even more. And if the whiskey in the barrels not ready to go into the bottle, it doesn't. But there's studies now showing that it regulates what's called neuroplasticity, which is like the ability, like your brain, your brain changes, you know, with the changing environment. That's excellent whiskey, but they're also producing high proof alcohol and hand sanitizer to aid in the fight against this virus. I mean, I think that you could just stay in for so so the thing so the thing is, is that like with most of the studies that have been done, looking at the benefits on cardiovascular health and all in all, cause mortality quite a bit lower, like twenty minutes at one hundred and seventy four degrees. Your wife must love it. What difference? Well, it's just they say things that they don't really know what the fuck they're talking about. It works. You know, who wants to wear a mask, but maybe to open up the. Obese, also obese people are like three times more likely to be vitamin deficient in the United States. There was a study that was over twenty five randomized controlled trials. Glutathione Yeah. Rhondas goal is to ensure her levels of vitamin D remain roughly between 40 ng/ml and 50 ng/ml. And that's what happened with the RSV toddlers. This episode, the podcast is brought to you by Trager Grills. It's questions interesting because it's Zingana for it's also been identified to have activity against Sajko one antiviral activity against Sajko, one doesn't nootropic properties as well. What are the symptoms of it? And so I was up like I was up to like I'm fasting. I think that's going to make a big difference and test. It's on a tent. You may get it a little bit more. That's when I love it. My friends, thank you so much. Like, it just feels really it's a nice shock. You could say that, but to downplay that as the only role of vitamin D I encourage you to check out Dr. Stasha Gominak. If the levels are 20 ng/ml to 29 ng/ml, it is inadequate. There's like all this stuff about you bleeding, your gums bleed. What does the cytomegalovirus. It is hard. Like the more leg strength you had, like the improve, it was like some kind of crazy no to me. But that's kind of the concern. There's interesting studies that have shown, you know, like that the intravenous vitamin C is like dramatically reducing inflammation as well. But so there's been studies looking at vitamin D levels in the Somali population. Oh you can do outdoor photography. You're going to be paying a lot out, but you got to 220. And I think people will become less scared as these as these therapeutics do emerge, which which which they will, I'm sure. Next the song is kind of useless. Would it wouldn't be hot enough to kill it. Yeah. I think it's because it's the carnitine. So the xylitol gum somehow. And that's how a lot of people start. Zinc once a week. So vitamin D seems to be very critical, saying if you have it, if you don't barthe vitamin C orally, you need a big dose and it's still not going to have the same effect. It is. But also, I think even just treating patients like that have already been infected. And I would take these long, deep nose and the whole inside of my nose be like stinging and everything. Louis Simmons invented it because he had a herniated disc and the doctors are telling him, hey, we have to operate on you because you have this compressed disc. Has it not been well understand for like 20 years that not getting any sun has negative impacts on how you feel? No kaat why. I've written anything. But once you get yourself down, you just relax and all of your weight, see how other guys doing it. And they're still winning. 92000 shitheads who have half assed their whole life. So, I mean, that's. So, you know, it's only women sauna that I went in. So that's terrible. It exacerbates it. Do you, do you do like electrolyte replenishment. I mean, like, you know, just information that, you know, is interesting. I don't know. OK, almost like UV protector got got microbiome. And I've had those conversations in public Sana's before to where people are people like they start getting into the toxins and the whole thing. It's awful for so many of these people that didn't do anything wrong. Or they can just supplement, which I know a lot of vegetarians do. Yeah, it is. Like, what are you scared of? Bonus points if you can explain to us how all the renowned/fundamental studies which have done this stuff, have got away with it! You could do everything on it. That's what I've done in the past. This strategy that you guys have, you're not adjusting and adapting. Yeah. And that's why fire application that comes with the Trager Grill has fifteen hundred plus recipes. I forgot the name of the test, but yeah, that's that's the test. Well, there's a girl there's a girl using that. What, what's this headline. It's it's hard, you know, being being a mom that's you know, I have you know, I run a business and but I also like want to be a really good mother. I can't use that crap. Yeah, so that's been done. And, you know, I think that that itself it's an interesting field. And because I was like, is that like an Ignacia thing? And like their critics, it's animals and blah, blah, blah. When we were talking about song, when people that don't have access to a sauna, how much benefit can they get out of a hot bath? She typically takes 2 of the Nordic Naturals ProOmega 2000 and 4 of the Nordic Naturals Omega-3 Phospholipids daily. I think that's a really good hypothesis. So it's like, yeah, it's hard to balance is very difficult. Listen to this episode from The Joe Rogan Experience on Spotify. So that was like my my first Finnish sauna experience where it was like people are too open minded. In other words, like, you have to go back a week later and see if they have symptoms because that that's really important. He wants to party all day, every day. If not just I hope people are going to, you know, take their vitamin D or ask their doctor to take it, you know, but yeah, I think that in a couple of months. Rhonda has always believed adequate supplementation of vitamin D is essential, this is especially true due to the severity and destructive nature of COVID-19. It's really good. The dark one. And so there's been there's been two major like strains that have been identified and one of them. They just vaccinate. And thankfully, there are clinical trials, randomized controlled trials that are now ongoing and there are some that are recruiting. Like when you take like a young population, as you get older, your immune system does decline. A link has been established between stronger immune systems and vitamin D levels. But have you noticed an effect on your sleep at all? Right. For this reason, Dr. Rhonda Patrick is extremely important. So they're not as healthy, they're not as physically active and not whatever, even though those confounding factors are usually corrected for it's old. And it calculated me as being in REM sleep. I hope. It is. So but she said something and I was just like, you know, I'm so glad. I use every five days a vitamin D, so it's like a weekly dose because a lot of times these people are severely deficient. And so I took her we went to get the IBC and they did it was ten, ten grams that we did. There's more meta analysis. I just don't deal with it. The reason why it's so special is forget about this for a second. Right, the colonel. So who uses the sauna here Jamie. Oh, sleep is huge. Sure. You know, it'll be interesting to see the data from those trials, whether or not there's going to be an effect, it's not known. I'm like, bro, I so I did that 200. But it's a godsend. Just just for the fuck. And at that point I, I was like looking through everything on my toiletries and everything, like, what do I have to get rid of what's in there that could be harmful and smells like fluoride like in my toothpaste. We know that elderly people are more prone to a severe form, but it just made me think, what if this you know, previous previous viral exposure to something like CMB is is kind of like also kind of shaping people's immune responses in some way?
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